Antonio Conte’s men have struggled at the back with Davide Zappacosta and Cesar Azpilicueta being drafted to right wing-back role as replacement for Moses who has been out of action since October 14.
And Lampard admitted that the absence of the Super Eagles’ player has left a vacuum in the Stamford Bridge outfit’s defence.
“Moses is a miss,” Lampard told BT Sport.
“You wouldn’t have thought that 18 months ago with what he’s given them in the right-wing back position.
“[Conte] is covering it with Azpilicueta, he’s covering it with Zappacosta and it’s affecting the whole back five and I think he will want to get back to knowing what his three is and working on it through the week.
“The players are going to have to react because I don’t think Conte is a manager that will change his way. He might change players in the team but they’ll have to work.